Optical Imaging Lab
Institut für Neuroinformatik
Fakultät für Informatik
Ruhr-Universität Bochum
Universitätsstr. 150
44801 Bochum
Raum:
NB 3/32
Tel:
+49 (0)234 32-27845
Email:
dirk.jancke@ruhr-uni-bochum.de
Research of my group focuses on processing dynamics within the brain. Specifically, we investigate its capacities for plastic reorganization (remodeling, learning) and the underlying state transitions. Using Optical Imaging techniques we show how parameters given in the outer world are represented and processed across large neuronal populations. By additional employment of sophisticated data analysis and modeling we aim at deciphering the brain's computational strategies that generate behavior.
Optical imaging is unique in its capability of capturing the activity of millions of neurons at once (for a review see "VSDI: a new era in functional imaging of cortical dynamics" and our contribution therein). In combination with Optogenetics (i.e., light stimulation of specific target neurons and neuronal subnetworks) our approach provides an ideal access to both theoretical and experimental questions dealing with highly dynamic activity patterns observed across the brain.
Barzan, R., Bozkurt, B., Nejad, M. M., Süß, S. T., Surdin, T., Böke, H., Spoida, K., Azimi, Z., Grömmke, M., Eickelbeck, D., Mark, M. D., Rohr, L., Siveke, I., Cheng, S., Herlitze, S., & Jancke, D. (2024). Gain control of sensory input across polysynaptic circuitries in mouse visual cortex by a single G protein-coupled receptor type (5-HT2A). Nature Communications, 15(1), 8078. https://doi.org/10.1038/s41467-024-51861-1
Jancke, D., Herlitze, S., Kringelbach, M. L., & Deco, G. (2022). Bridging the gap between single receptor type activity and whole-brain dynamics. The FEBS Journal, 289(8), 2067–2084. https://doi.org/10.1111/febs.15855
Kozyrev, V., Staadt, R., Eysel, U. T. & Jancke, D. (2018). TMS-induced neuronal plasticity enables targeted remodeling of visual cortical maps. Proceedings of the National Academy of Sciences of the United States of America, 115(25), 6476–6481. https://doi.org/10.1073/pnas.1802798115
Rekauzke, S., Nortmann, N., Staadt, R., Hock, H. S., Schöner, G. & Jancke, D. (2016). Temporal Asymmetry in Dark–Bright Processing Initiates Propagating Activity across Primary Visual Cortex. The Journal of Neuroscience, 36(6), 1902–1913. https://doi.org/10.1523/jneurosci.3235-15.2016
Nortmann, N., Rekauzke, S., Onat, S., König, P. & Jancke, D. (2015). Primary Visual Cortex Represents the Difference Between Past and Present. Cerebral Cortex, 25(6), 1427–1440. https://doi.org/10.1093/cercor/bht318
Kozyrev, V., Eysel, U. T. & Jancke, D. (2014). Voltage-sensitive dye imaging of transcranial magnetic stimulation-induced intracortical dynamics. Proceedings of the National Academy of Sciences of the United States of America, 111(37), 13553–13558. https://doi.org/10.1073/pnas.1405508111
Palagina, G., Eysel, U. T. & Jancke, D. (2009). Strengthening of lateral activation in adult rat visual cortex after retinal lesions captured with voltage-sensitive dye imaging in vivo. Proceedings of the National Academy of Sciences of the United States of America, 106(21), 8743–8747. https://doi.org/10.1073/pnas.0900068106
Jancke, D., Chavane, F., Naaman, S. & Grinvald, A. (2004). Imaging cortical correlates of illusion in early visual cortex. Nature, 428(6981), 423–426. https://doi.org/10.1038/nature02396
Jancke, D. (2000). Orientation Formed by a Spot’s Trajectory: A Two-Dimensional Population Approach in Primary Visual Cortex. The Journal of Neuroscience, 20(14), RC86. https://doi.org/10.1523/jneurosci.20-14-j0005.2000
Jancke, D., Erlhagen, W., Dinse, H. R., Akhavan, A. A., Giese, M. A., Steinhage, A. & Schöner, G. (1999). Parametric Population Representation of Retinal Location: Neuronal Interaction Dynamics in Cat Primary Visual Cortex. The Journal of Neuroscience, 19(20), 9016–9028. https://doi.org/10.1523/jneurosci.19-20-09016.1999
Copyright © RDN 2025
Letzte Änderung: 26. Mär. 2025
