Department of Medical Psychology and Medical Sociology
Faculty of Medicine
Ruhr University Bochum
Universitätsstr. 105
44789 Bochum
Room:
1/35
Phone:
+49 (0)234 32-25438
Email:
franziska.labrenz@ruhr-uni-bochum.de
Interoceptive sensations from the internal organs, such as visceral pain, differ in many aspects from other pain modalities and are characterized by complex mechanisms in the bidirectional communication between the gut and brain. Disorders of gut-brain interaction are highly prevalent worldwide and often associated with high morbidity as well as reduced quality of life in patients. My research interest focusses on the investigation of various biological, psychological and social factors that impact upon the development and maintenance of chronic visceral pain. Using clinically relevant models in behavioral experiments and studies with structural and functional neuroimaging, I explore how pain-related learning and memory processes, attention, stress, and anxiety can influence the perception and processing of visceral pain.
Benson, S., Labrenz, F., Kotulla, S., Brotte, L., Rödder, P., Tebbe, B., Theysohn, N., Engler, H., & Elsenbruch, S. (2023). Amplified gut feelings under inflammation and depressed mood: A randomized fMRI trial on interoceptive pain in healthy volunteers. Brain, Behavior, and Immunity, 112, 132–137. https://doi.org/10.1016/j.bbi.2023.06.005
Labrenz, F., Merz, C. J., & Icenhour, A. (2023). Connecting dots in disorders of gut-brain interaction: The interplay of stress and sex hormones in shaping visceral pain. Frontiers in Psychiatry, 14, 1204136. https://doi.org/10.3389/fpsyt.2023.1204136
Labrenz, F., Woud, M. L., Elsenbruch, S., & Icenhour, A. (2022). The Good, the Bad, and the Ugly-Chances, Challenges, and Clinical Implications of Avoidance Research in Psychosomatic Medicine. Frontiers in Psychiatry, 13, 841734. https://doi.org/10.3389/fpsyt.2022.841734
Labrenz, F., Spisák, T., Ernst, T. M., Gomes, C. A., Quick, H. H., Axmacher, N., Elsenbruch, S., & Timmann, D. (2022). Temporal dynamics of fMRI signal changes during conditioned interoceptive pain-related fear and safety acquisition and extinction. Behavioural Brain Research, 427, 113868. https://doi.org/10.1016/j.bbr.2022.113868
Labrenz, F., Ferri, F., Wrede, K., Forsting, M., Schedlowski, M., Engler, H., Elsenbruch, S., Benson, S., & Costantini, M. (2019). Altered temporal variance and functional connectivity of BOLD signal is associated with state anxiety during acute systemic inflammation. NeuroImage, 184, 916–924. https://doi.org/10.1016/j.neuroimage.2018.09.056
Elsenbruch, S., & Labrenz, F. (2018). Nocebo Effects and Experimental Models in Visceral Pain. International Review of Neurobiology, 138, 285–306. https://doi.org/10.1016/bs.irn.2018.01.010
Labrenz, F., Wrede, K., Forsting, M., Engler, H., Schedlowski, M., Elsenbruch, S., & Benson, S. (2016). Alterations in functional connectivity of resting state networks during experimental endotoxemia - An exploratory study in healthy men. Brain, Behavior, and Immunity, 54, 17–26. https://doi.org/10.1016/j.bbi.2015.11.010
Labrenz, F., Icenhour, A., Schlamann, M., Forsting, M., Bingel, U., & Elsenbruch, S. (2016). From Pavlov to pain: How predictability affects the anticipation and processing of visceral pain in a fear conditioning paradigm. NeuroImage, 130, 104–114. https://doi.org/10.1016/j.neuroimage.2016.01.064
Labrenz, F., Icenhour, A., Benson, S., & Elsenbruch, S. (2015). Contingency Awareness Shapes Acquisition and Extinction of Emotional Responses in a Conditioning Model of Pain-Related Fear. Frontiers in Behavioral Neuroscience, 9, 318. https://doi.org/10.3389/fnbeh.2015.00318
Labrenz, F., Icenhour, A., Thürling, M., Schlamann, M., Forsting, M., Timmann, D., & Elsenbruch, S. (2015). Sex differences in cerebellar mechanisms involved in pain-related safety learning. Neurobiology of Learning and Memory, 123, 92–99. https://doi.org/10.1016/j.nlm.2015.05.006
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Last update: Feb 28, 2024
